New Discoveries in Protein Methylation

A ground-breaking report from scientists at Glaxo and Epizyme has now revealed that the PRMT1 inhibitor, GSK3368715, exhibits potent anti-tumor activity. Extensive chemical and cellular studies support the usefulness of the new chemical compound as a First-In-Class therapeutic agent. Also described in the report are experiments that implicate the endogenous metabolic inhibitor, methyl-thioadenosine (MTA), in … Read more

Current Research Using the E0771 Cell Line

The use of E0771 cells in cancer metastasis research is rapidly increasing in popularity. Researchers are attracted to the aggressive nature and immune system evading properties of the cells. One of the main interests of researchers using these cells is the role of immune cell antitumor functions in the regulation of cancer spread. Immune Responses … Read more

Research Review Series (2 of 3)

THE INTERSECTION OF CANCER AND PROTEIN METHYLATION   William Pratt, CH3 Biosystems Lab Intern Introduction   Protein arginine methyltransferases (PRMTs) are transcriptional coactivators, a type of coregulator that affects a transcription factor to increase the rate of transcription of a gene by recruiting general transcription machinery to the promoter region. The aberrant expression of PRMTs … Read more

Research Spotlight

Methyltransferase Inhibitors Recent exciting news in the field of personalized medicine of cancer patients: new developments on the collaboration between Epizyme and GlaxoSmithKline may contribute the advancement of cancer treatment research tremendously.  Additionally, there has been new progress made by CH3 BioSystems to create a new drug discovery platform. New development on the collaboration between … Read more

Product Spotlight

Cell Lines Cell lines are derived from normal or diseased tissue that is disaggregated and subjected to limited dilution to generate one or a few cells. Therefore, after several dozen rounds of division, cultures of cell line consist of cells with uniform genetic make-up and additionally homogenous biochemical composition. Here at CH3 BioSystems, our cell lines are … Read more