Important Translational Research News About Fragile X Mental Retardation and Cancer

CH3 BioSystems is excited about an important review article recently published by Majumder et al. that helps to explain the role of methylarginine modification in the functional regulation the fragile X family of proteins with implications for neurodevelopment and cancer. In conjunction with phospho-serine modifications of these methyl-proteins, the molecular mechanisms involved are likely to involve the phase separation of membrane-less protein assemblies needed for the transport and translation of mRNA. More details on the phase separation process can be found in a 2019 paper by Tsang et al. which references a study co-authored by CH3 BioSystems’ principal scientist John M Aletta. Check back here soon to learn more about research that is expanding knowledge in the field of protein arginine methylation!