CH3 BioSystems is excited about an important review article recently published by Majumder et al. that helps to explain the role of methylarginine modification in the functional regulation the fragile X family of proteins with implications for neurodevelopment and cancer. In conjunction with phospho-serine modifications of these methyl-proteins, the molecular mechanisms involved are likely to involve the phase separation of membrane-less protein assemblies needed for the transport and translation of mRNA. More details on the phase separation process can be found in a 2019 paper by Tsang et al. which references a study co-authored by CH3 BioSystems’ principal scientist John M Aletta. Check back here soon to learn more about research that is expanding knowledge in the field of protein arginine methylation!