NF kappa B joins other signaling molecules modified by methylation

NF kappa B joins other signaling molecules modified by methylation

CH3 BioSystemsIn normal cells exposed to stress, the central transcription factor NF-κB is activated only transiently, to modulate the activation of downstream immune responses. However, in most cancers, NF-κB is abnormally activated constitutively, contributing thus to oncogenesis and tumor progression. Therefore, downregulating NF-κB activity is an important goal of cancer treatment.

Read More http://www.ncbi.nlm.nih.gov/pubmed/26337909

John Aletta
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