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HepG2 Cell Line Human Hepatoma G2 Hepatocellular Carcinoma Cell Line
Price range: $600.00 through $750.00
HepG2 cells are powerful accessible immortalized cell models of metabolic activity. As with other cell culture models, the homogeneous nature of HepG2 cultures allows for simplified biochemical analysis without interference from a variety of support cells that are present in animal tissues. These cells are especially useful for pharmaceutical and biotech companies interested in new drug DMPK and toxicity studies in animal models. Metabolism and processing of drug molecules are more easily and cheaply monitored in HepG2 cultured cells than in whole animal models. Pilot studies in HepG2 cells can support and supplement data from animal pharmacokinetics.
- Metabolism: The chemical modification and degradation of drugs and biomolecules by cytochromes and intra-cellular enzymes. HepG2 cells, like the principle cells of the animal liver, are rich sources of cytochromes and metabolic enzymes.
- Immortalized: A HepG2 cell line can be maintained indefinitely under the proper culture and storage conditions
- DMPK: Distribution, metabolism and pharmacokinetics
- Toxicity: Deleterious side effects of drugs that result in deteriorating health
- Support Cells: Epithelial cells, blood cells and other cells that support the various metabolic functions of hepatocytes in the liver. Some support cells, for example are responsible for the storage of vitamin A for the body.
HepG2 Cell Line
Hepatoma G2, Human hepatocellular carcinoma
Product: #93A001
Overview
Human hepatocellular carcinoma cell line.
Purification
N/A
Formulation
10 to 20 X 106 cells in flask containing RPMI 1640 culture medium and 5% fetal bovine serum or frozen cell pellet in cryoprotectant.
Product Usage
Cell culture. Useful for large-scale cell culture to provide cell proteins for purification in downstream applications. Adapt well to a wide variety of culture media. Fetal bovine serum at 5% is recommended.
Testing
Cultured on tissue culture plastic in 5% fetal bovine serum with either DMEM or RPMI 1640.
Storage
Place in culture immediately upon arrival; 35° humidified CO2 incubator. Use 5 to 7.5% CO2.
| Weight | N/A |
|---|---|
| Dimensions | N/A |
| Premium | Tested, Regular |
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