Histone methylation modifiers in cellular signaling pathways

Histone methylation modifiers in cellular signaling pathways Histone methyltransferases and demethylases epigenetically regulate gene expression by modifying histone methylation status in numerous cellular processes, including cell differentiation and proliferation. These modifiers also control methylation levels… Read More

QM/MM MD and Free Energy Simulation Study of Methyl Transfer Processes Catalyzed by PKMTs and PRMTs.

QM/MM MD and Free Energy Simulation Study of Methyl Transfer Processes Catalyzed by PKMTs and PRMTs. Methyl transfer processes catalyzed by protein lysine methyltransferases (PKMTs) and protein arginine methyltransferases (PRMTs) control important biological events including transcriptional regulation and cell signaling. Read More on NCBI

Methylated CREB binding protein is nuclear – Sept 2015

Methylated CREB binding protein is nuclear Proper embryonic development requires a fine-tuned control of gene expression, which is achieved in part through the activity of transcription coactivators or corepressors. The nuclear coactivator cAMP-response element-binding protein (CREB) binding protein (CREBBP or CBP) interacts with numerous transcription factors and thereby plays a Read More on NCBI Site

Tumors, p53 and survivin

Expression Vector

A recent New York Times article published on December 22, 2012 described efforts to develop new drug compounds capable of targeting cancer cells that arise in many different organs of the human body.  Unfortunately, much was left unsaid with little source information to track down more specifics.  Fierce Biotech regurgitated the essentials of the article, but little in the way of … Read more